Biology of Business

Bacteria

Bacteria are the original lean startups—organisms stripped to the minimum viable components that can reproduce. No nucleus, no organelles, no complexity that doesn't directly serve replication. A bacterium divides every 20 minutes under optimal conditions, meaning one cell becomes a billion in 10 hours. This isn't just fast—it's fast enough to evolve visibly within human lifetimes. The strategic implications are profound. Bacteria don't plan; they iterate. Antibiotic resistance doesn't require intelligence—it requires enough random variation that some individuals survive, combined with fast enough reproduction that survivors dominate within days. The bacterial strategy is brute-force search: generate millions of variants, let the environment select winners, repeat. It's evolution as algorithm. Bacteria also invented horizontal gene transfer—sharing genetic information between unrelated individuals. This is open-source biology: innovations spread laterally across species, not just vertically through generations. A resistance gene that evolves in one bacterium can transfer to completely different species. The bacterial commons accelerates adaptation beyond what any single lineage could achieve. The business parallels are uncomfortable. Bacteria succeed through strategies that would horrify corporate strategists: no planning, no differentiation, no competitive moat. Just speed, variation, and ruthless selection. Yet bacterial 'companies' have dominated Earth for 3.5 billion years while every sophisticated competitor has gone extinct multiple times. When exploring bacteria in this section, look for: iteration speed (how does fast reproduction substitute for planning?), horizontal transfer (how does information sharing accelerate adaptation?), and minimal viable organisms (what can you strip away and still succeed?).

Acinetobacter baumannii

Acinetobacter baumannii earned the nickname 'Iraqibacter' during the Iraq War, when it caused devastating wound infections in military personnel. But...

Actinoplanes

Actinoplanes species produce acarbose, an alpha-glucosidase inhibitor used to treat type 2 diabetes. This compound slows carbohydrate digestion, reduc...

Aeromonas salmonicida

Aeromonas salmonicida causes furunculosis, a devastating disease of salmon and trout aquaculture. Like Vibrio species, A. salmonicida uses quorum sens...

Agrobacterium tumefaciens

Agrobacterium tumefaciens performs what may be nature's most audacious act of horizontal gene transfer: it inserts its own DNA into plant chromosomes,...

Aliivibrio logei

Aliivibrio logei represents the cold-water counterpart to Vibrio fischeri's temperate lifestyle. Both bacteria form bioluminescent symbioses with squi...

Amycolatopsis rifamycinica

Amycolatopsis rifamycinica produces rifamycins, antibiotics that became pillars of tuberculosis treatment alongside streptomycin and isoniazid. The di...

Anabaena

Anabaena demonstrates that bacteria can evolve multicellular organization with division of labor. This filamentous cyanobacterium grows as chains of c...

Antibiotic-Producing Bacteria

Leafcutter ants carry pharmaceutical factories on their bodies. Pseudonocardia bacteria grow in specialized structures on ant cuticles, producing anti...

Azoarcus sp. BH72

Azoarcus sp. BH72 was isolated from Kallar grass in Pakistan, a salt-tolerant plant growing in saline soils without fertilizer. The bacterium colonize...

Azospirillum brasilense

Azospirillum brasilense represents a different model of plant-microbe mutualism than nodule-forming rhizobia. Rather than forming specialized structur...

Azotobacter

Azotobacter are free-living soil bacteria capable of fixing atmospheric nitrogen without requiring plant symbiosis. They possess the nitrogenase enzym...

Azotobacter vinelandii

Azotobacter vinelandii fixes nitrogen without any plant partner—a remarkable feat given that nitrogen fixation requires protection from oxygen, which...

Bacillus subtilis

Bacillus subtilis has evolved one of nature's most elegant systems for genetic adaptation: natural competence. Unlike E. coli, which primarily receive...

Bdellovibrio bacteriovorus

Bdellovibrio bacteriovorus is a bacterial shark—a tiny, fast-swimming predator that hunts, kills, and consumes other bacteria. Unlike myxobacteria's c...

Bradyrhizobium japonicum

Bradyrhizobium japonicum forms the foundational partnership underlying global soybean production. This slow-growing bacterium—hence 'brady' meaning sl...

Buchnera

Buchnera are endosymbiotic bacteria living within aphid cells that synthesize amino acids aphids cannot produce from plant sap. They are transmitted v...

Burkholderia cepacia

Burkholderia cepacia complex represents a group of closely related species that have become notorious in cystic fibrosis care. Like Pseudomonas aerugi...

Chondromyces crocatus

Chondromyces crocatus builds fruiting bodies that challenge our understanding of bacterial capabilities. These structures reach 1 millimeter in height...

Chromobacterium violaceum

Chromobacterium violaceum has become a workhorse for quorum sensing research precisely because its communication system produces a visible output: vio...

Chroococcidiopsis

Chroococcidiopsis defines the boundary between life and lifelessness. This cyanobacterium survives conditions that kill everything else: the hyperarid...

Cryptoendolithic Organisms

Cryptoendolithic organisms live inside rocks in Antarctica's dry valleys—one of Earth's most Mars-like environments. Temperatures average -20°C, liqui...

Cupriavidus taiwanensis

Cupriavidus taiwanensis shatters assumptions about which bacteria can form nitrogen-fixing symbioses. This member of the Burkholderiaceae—a family not...

Cyanobacteria

Cyanobacteria are the reason you're reading this. 2.4 billion years ago, these photosynthetic bacteria evolved a new trick: splitting water molecules...

Cyanobacterial Akinetes

Akinetes are thick-walled dormant cells produced by cyanobacteria when conditions deteriorate. These survival structures can persist for centuries—via...

Cystobacter fuscus

Cystobacter fuscus demonstrates how cell adhesion shapes collective behavior in predatory bacteria. Unlike some myxobacteria where cells maintain loos...

Cytophaga hutchinsonii

Cytophaga hutchinsonii glides across surfaces faster than any other bacterium—up to 15 micrometers per second. This remarkable motility, combined with...

Deinococcus radiodurans

Deinococcus radiodurans—nicknamed 'Conan the Bacterium'—can survive radiation doses 1,000 times higher than would kill a human. Its genome gets shatte...

Enterococcus faecalis

Enterococcus faecalis has refined horizontal gene transfer into something approaching a marketplace. While E. coli exchanges genes somewhat randomly t...

Escherichia coli

E. coli serves as the chapter's primary biological example, demonstrating how a single-celled organism with no brain or nervous system makes better re...

Frankia

Frankia represents an entirely independent evolution of plant-microbe nitrogen fixation. While Rhizobium and its relatives partner with legumes, Frank...

Fusobacterium nucleatum

Fusobacterium nucleatum serves as the great connector of oral biofilm ecology. This spindle-shaped bacterium possesses surface adhesins that bind to b...

Gloeocapsa

Gloeocapsa blackens rocks worldwide—from tropical monuments to arctic cliffs. This cyanobacterium produces dark pigments protecting against UV radiati...

Gluconacetobacter diazotrophicus

Gluconacetobacter diazotrophicus solved the puzzle of how Brazilian sugarcane thrives with minimal nitrogen fertilizer. This bacterium lives inside su...

Haemophilus influenzae

Haemophilus influenzae holds a unique place in biological history: it was the first free-living organism to have its complete genome sequenced, in 199...

Helicobacter pylori

Helicobacter pylori has made a permanent home in one of the most hostile environments imaginable: the human stomach. To survive in an acid bath that k...

Herbaspirillum seropedicae

Herbaspirillum seropedicae colonizes grasses promiscuously, forming endophytic associations with rice, maize, sorghum, and sugarcane. Unlike Rhizobium...

Kitasatospora

Kitasatospora was originally classified within Streptomyces but proved distinct enough for separate genus status. This taxonomic separation correlated...

Klebsiella pneumoniae

Klebsiella pneumoniae has become the poster child for antibiotic resistance acquisition, demonstrating how horizontal gene transfer can outpace human...

Legionella pneumophila

Legionella pneumophila caused panic when it first emerged in 1976, killing 29 American Legion convention attendees in Philadelphia. The culprit proved...

Lysobacter enzymogenes

Lysobacter enzymogenes represents a predatory strategy intermediate between myxobacterial swarming and Bdellovibrio's individual hunting. This gliding...

Mesorhizobium loti

Mesorhizobium loti partners with Lotus japonicus, forming a model symbiosis that complements the Sinorhizobium-Medicago system. Where Medicago forms i...

Microcystis

Microcystis aeruginosa forms the toxic algal blooms that close beaches, contaminate drinking water, and kill livestock worldwide. This colonial cyanob...

Micromonospora

Micromonospora ranks second only to Streptomyces in the number of antibiotics discovered, including gentamicin and other aminoglycosides that remain c...

Mitochondria

Mitochondria are ancient bacterial invaders that became so essential you cannot imagine life without them. Between 1.5 and 2 billion years ago, an anc...

Myxobacteria

Myxobacteria are soil bacteria that use quorum sensing to coordinate multicellular development. When nutrients are depleted and population density is...

Myxococcus xanthus

Myxococcus xanthus has become the primary model for bacterial social behavior because it displays the full range of myxobacterial cooperative phenomen...

Neisseria gonorrhoeae

Neisseria gonorrhoeae has evolved perhaps the most sophisticated immune evasion system in the bacterial world: programmed antigenic variation. Rather...

Nitrobacter

Nitrobacter are nitrifying bacteria that complete the second step of nitrification, oxidizing nitrite (NO₂⁻) to nitrate (NO₃⁻). This produces the form...

Nitrosomonas

Nitrosomonas are nitrifying bacteria that oxidize ammonia (NH₄⁺) to nitrite (NO₂⁻), obtaining energy from this chemical transformation. They represent...

Nocardia

Nocardia species are known both as opportunistic pathogens and as sources of bioactive compounds. This dual identity—some species cause disease while...

Nostoc

Nostoc appears mysteriously after rains—gelatinous masses seeming to materialize from nowhere, leading to folk names like 'star jelly' and 'witch's bu...

Oscillatoria

Oscillatoria demonstrates that even bacteria without flagella can move with purpose. This filamentous cyanobacterium glides along surfaces through an...

Paenibacillus vortex

Paenibacillus vortex creates the most complex bacterial colony patterns known—intricate branching structures, rotating vortices, and fractal-like morp...

Photobacterium leiognathi

Photobacterium leiognathi demonstrates that the Vibrio fischeri-squid symbiosis has a parallel in fish. This bacterium colonizes the light organs of p...

Photobacterium phosphoreum

Photobacterium phosphoreum illuminates the ocean in ways Vibrio fischeri cannot. While V. fischeri achieves its spectacular bioluminescence through sy...

Photorhabdus luminescens

Photorhabdus luminescens brings bioluminescence to land through a remarkable three-way symbiosis. The bacterium lives mutualistically inside entomopat...

Porphyromonas gingivalis

Porphyromonas gingivalis has redefined our understanding of pathogenesis through its role as a 'keystone pathogen.' Despite comprising less than 0.01%...

Prochlorococcus

Prochlorococcus is the smallest known photosynthetic organism—a cyanobacterium streamlined to the absolute minimum needed for survival in the nutrient...

Proteus mirabilis

Proteus mirabilis creates some of the most striking patterns in microbiology: concentric rings of bacterial growth expanding across agar plates like r...

Pseudomonas aeruginosa

Pseudomonas aeruginosa doesn't attack immediately. At low population density in a wound or lung, it stays silent - producing no toxins, revealing no p...

Pseudomonas fluorescens

Pseudomonas fluorescens demonstrates that the same biofilm capabilities making P. aeruginosa a dangerous pathogen can serve beneficial purposes. This...

Rhizobia Bacteria

Rhizobia are nitrogen-fixing bacteria that form symbiotic relationships with legume plants. They convert atmospheric nitrogen (N₂) to ammonia, which p...

Rhizobium

Rhizobium bacteria convert atmospheric nitrogen into ammonia inside legume root nodules - a biochemical feat that plants cannot perform themselves. Th...

Rhizobium

Rhizobium bacteria form nodules on legume roots that perform a feat of chemistry no plant can manage alone: converting atmospheric nitrogen into ammon...

Saccharopolyspora erythraea

Saccharopolyspora erythraea produces erythromycin, a macrolide antibiotic that became essential for patients allergic to penicillin and for infections...

Salinispora tropica

Salinispora tropica rewrote assumptions about actinomycete ecology when it was discovered in 2005 as the first obligate marine actinomycete. Unlike te...

Salmonella

Salmonella demonstrates exponential growth at its extreme: under ideal conditions, populations can double every 20 minutes. This is among the fastest...

Salmonella typhimurium

Salmonella typhimurium represents one of nature's most sophisticated examples of adaptive gene acquisition under pressure. Like its close relative E....

Serratia marcescens

Serratia marcescens once performed miracles—or so medieval observers believed when communion bread mysteriously bled red. The 'blood' was actually pro...

Shewanella woodyi

Shewanella woodyi brings bioluminescence to the Shewanella genus, a group otherwise known for remarkable respiratory versatility rather than light pro...

Shigella flexneri

Shigella flexneri provides the clearest illustration of how horizontal gene transfer can transform an organism's ecological role. Genetically, Shigell...

Sinorhizobium meliloti

Sinorhizobium meliloti has become the model organism for understanding how nitrogen-fixing symbioses work at the molecular level. Its partnership with...

Sorangium cellulosum

Sorangium cellulosum holds the record for the largest bacterial genome—13 million base pairs, three times larger than E. coli. This genomic enormity i...

Spirulina

Spirulina (Arthrospira) transforms the cyanobacterial photosynthesis engine into human food. This filamentous cyanobacterium has been harvested as foo...

Staphylococcus aureus

Staphylococcus aureus represents one of humanity's most persistent bacterial adversaries, combining biofilm expertise with remarkable genetic adaptabi...

Stenotrophomonas maltophilia

Stenotrophomonas maltophilia represents the emerging challenge of intrinsically resistant organisms. Unlike bacteria that acquire resistance through h...

Stigmatella aurantiaca

Stigmatella aurantiaca produces the most elaborate fruiting bodies among myxobacteria—branching, tree-like structures that elevate spore-containing he...

Streptomyces coelicolor

Streptomyces coelicolor became the E. coli of actinomycete biology—the model organism whose deep genetic characterization illuminates the entire group...

Streptomyces griseus

Streptomyces griseus holds a unique place in medical history: it's the source of streptomycin, the first antibiotic effective against tuberculosis. Di...

Swarming Bacteria

Proteus mirabilis bacteria exhibit locust-like phase transitions at microscopic scale. At low density, cells swim independently through liquid. When s...

Synechococcus

Synechococcus complements Prochlorococcus in the ocean's photosynthetic workforce, dominating coastal and upwelling waters where Prochlorococcus strug...

Trichodesmium

Trichodesmium has mastered a trick that seemed impossible: fixing nitrogen in the oxygen-rich open ocean without specialized heterocyst cells. This co...

Vibrio cholerae

Vibrio cholerae reveals how environmental context shapes the strategy of horizontal gene transfer. In open water, this bacterium is relatively benign,...

Vibrio fischeri

Vibrio fischeri lives in two worlds. Free-swimming in the ocean at low density, it's invisible - producing no light. Colonizing a squid's light organ...

Vibrio harveyi

Vibrio harveyi has become the premier model for understanding complex quorum sensing because it uses not one but three parallel communication systems....

Vibrio parahaemolyticus

Vibrio parahaemolyticus shares quorum sensing machinery with V. fischeri but uses it for opposite purposes: causing seafood-borne illness rather than...

Vibrio vulnificus

Vibrio vulnificus represents the lethal extreme of the Vibrio genus that includes benign symbionts like V. fischeri. This bacterium causes the deadlie...