Sirtuins
A family of NAD⁺-dependent enzymes that regulate cellular health, stress resistance, and longevity. Sirtuins are activated by nutrient scarcity and caloric restriction.
Biological Context
Sirtuins help repair DNA, silence genes appropriately, and improve metabolic efficiency. They're part of why caloric restriction extends lifespan—restriction activates sirtuins, which improve cellular maintenance. SIRT6 overexpression extends mouse lifespan by 15%. Sirtuins represent the body's 'do more with less' adaptation.
Business Application
Sirtuin-like responses in organizations: resource scarcity that triggers improved efficiency and maintenance rather than just suffering. Companies that activate their 'sirtuins' during lean times emerge healthier; those that just shrink without adaptation emerge weaker.