Genetics
Methylation
The addition of a methyl group to DNA or proteins, often silencing gene expression. A key epigenetic mechanism that doesn't change DNA sequence but affects its function.
Biological Context
DNA methylation typically silences genes—heavily methylated regions aren't transcribed. Methylation patterns can be inherited across cell divisions and sometimes across generations. Aberrant methylation is involved in cancer, aging, and developmental disorders. Environmental factors can influence methylation.
Business Application
Organizational methylation: processes that silence certain capabilities or knowledge without destroying them. Archived projects, dormant skills, or suppressed innovations can be 'demethylated' (reactivated) when needed.