MindMaze

MindMaze pioneered digital neurotherapeutics by gamifying stroke rehabilitation and cognitive therapy. Founded in 2012 by neuroscientist Tej Tadi, the company's VR platform allows stroke patients to practice motor skills in virtual environments that provide real-time feedback - dramatically increasing therapy engagement compared to traditional exercises. This approach exploits neuroplasticity: the brain rewires itself through repetition, and gamification increases repetitions by making therapy less tedious. MindMaze's $1B+ peak valuation (2016) attracted strategic investors including Hinduja Group, but the company illustrates digital health's challenge: proving clinical efficacy and securing reimbursement takes longer than consumer software, requiring patient capital most VCs can't provide.