Citation

The Distribution of Cellular Turnover in the Human Body

Sender, Ron, Milo, Ron

Nature Medicine (2021)

TL;DR

Humans replace approximately 330 billion cells per day (0.33 × 10¹² ± 0.02)

This landmark Weizmann Institute study provides the rigorous quantification behind the chapter's claim that humans replace approximately 330 billion cells per day. This isn't a metaphor - it's measured science.

For business readers, this research underscores that healthy organisms are constantly turning over their components. The stability you see (a body, a culture) is the result of constant replacement and renewal, not static preservation. Organizations that resist all turnover are fighting biology.

Key Findings from Sender & Milo (2021)

  • Humans replace approximately 330 billion cells per day (0.33 × 10¹² ± 0.02)
  • 86% of replaced cells are blood cells
  • 12% are gastrointestinal epithelial cells
  • Total cellular mass turnover is 80 ± 20 grams per day

Related Mechanisms for The Distribution of Cellular Turnover in the Human Body

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