Citation
Quorum sensing inhibitors: a bargain of effects
TL;DR
Quorum sensing can be disrupted by enzymes that degrade autoinducers
This paper reviewed therapeutic strategies for disrupting bacterial quorum sensing (quorum quenching) as an alternative to antibiotics. By interfering with coordination rather than killing bacteria, quorum quenching represents a new approach to treating infections.
The concept has broader implications: disrupting competitor coordination can be as effective as direct competition, and coordination mechanisms must be designed to resist interference.
Key Findings from Rasmussen & Givskov (2006)
- Quorum sensing can be disrupted by enzymes that degrade autoinducers
- Competitive inhibitors can block quorum-sensing receptors
- Quorum quenching may provide alternative to antibiotics
- Therapeutic interference with coordination is a viable strategy