Citation
The multifaceted mismatch-repair system
TL;DR
Mismatch repair contributes >100-fold to replication fidelity
Detailed analysis of mismatch repair contributing over 100-fold to replication fidelity. Demonstrates how this single repair pathway provides enormous protection against replication errors, yet is itself part of a redundant system of multiple repair mechanisms.
Key Findings from Jiricny (2006)
- Mismatch repair contributes >100-fold to replication fidelity
- Multiple proteins perform similar functions within the pathway
- System identifies errors and determines which strand contains the error
- Part of broader redundant repair network