Citation
Role of linkers in communication between protein modules
TL;DR
Linker sequences enable domain independence
This paper explains the mechanism that enables protein domain modularity to work - the linker sequences that connect domains. The research shows that domains can fold independently because linkers provide flexibility without disrupting domain structure.
This is directly analogous to organizational interface design: the 'linkers' between business modules must enable independence while permitting functional integration when needed. The paper supports the chapter's argument that effective modularity requires both independence (modules that work correctly in isolation) and integration (mechanisms for modules to cooperate).
Key Findings from Gokhale & Khosla (2000)
- Linker sequences enable domain independence
- Domains fold properly regardless of other domains in the same protein
- Linkers are flexible enough to accommodate different spatial arrangements
- Independence enables recombination while integration enables sophisticated function