Citation
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction
TL;DR
TTX resistance involves specific amino acid substitutions at TTX binding site
This molecular-level analysis revealed the precise genetic mechanisms underlying snake resistance to newt toxin - amino acid substitutions in voltage-gated sodium channels. It showed how reciprocal selection drives molecular evolution at specific gene sites.
For business strategy, this demonstrates that competitive adaptations often require specific, costly changes at fundamental levels of operation - not just surface-level responses.
Key Findings from Geffeney et al. (2005)
- TTX resistance involves specific amino acid substitutions at TTX binding site
- Mutations reduce toxin's ability to block nerve signals
- Multiple independent evolutionary origins of resistance
- Molecular evidence confirms reciprocal selection driving co-evolution