Citation

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., Walker, G.C.

Environmental and Molecular Mutagenesis (2017)

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TL;DR

Multiple DNA repair pathways address different damage types

Comprehensive review of DNA repair pathways demonstrating redundant repair mechanisms. The paper explains how multiple overlapping pathways (BER, NER, MMR, HR, NHEJ) provide layered protection against different types of DNA damage, with pathways overlapping to provide backup when one is impaired.

Key Findings from Chatterjee & Walker (2017)

  • Multiple DNA repair pathways address different damage types
  • Pathways overlap providing backup if one is impaired
  • Internal redundancy within pathways provides robustness
  • Repair redundancy calibrated to balance protection against costs

Related Mechanisms for Mechanisms of DNA damage, repair, and mutagenesis

DNA Repair Mechanisms

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