Citation
CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy)
TL;DR
25% caloric restriction over 2 years in healthy adults
CALERIE is the first controlled human trial of caloric restriction, though limited to 2 years. It provides direct evidence that CR mechanisms operate in humans, not just model organisms. Participants showed improved metabolic markers, reduced oxidative stress, and better cardiovascular indicators.
For business applications, CALERIE suggests the restriction framework isn't just animal biology - the same mechanisms that extend worm lifespan improve human metabolic health, supporting the translation to organizational contexts.
Key Findings from Group (2015)
- 25% caloric restriction over 2 years in healthy adults
- Improved insulin sensitivity and cardiovascular markers
- Reduced oxidative stress and inflammation
- Quality of life maintained despite restriction